[摘要] 目的 分析G-桿菌耐藥性變遷與抗菌藥物使用頻度之間的關系，為合理應用抗菌藥物提供依據(jù)。方法 回顧分析2013～2016年4種G-桿菌耐藥性變遷，統(tǒng)計抗菌藥物使用頻度（DDDs），采用Pearson相關分析法考察兩者相關性。結(jié)果 G-桿菌檢出率前四位是大腸埃希菌、肺炎克雷伯菌、銅綠假單胞菌和鮑曼不動桿菌；二代和三代頭孢類、硝咪唑類、喹諾酮類DDDs排序居前；大腸埃希菌對左氧氟沙星耐藥率與喹諾酮類和三代頭孢DDDs呈顯著正相關（r=0.956、0.959，P<0.05）；肺炎克雷伯菌對哌拉西林/他唑巴坦耐藥率與二代頭孢DDDs呈中度正相關（r=0.617，P<0.05），對阿莫西林/克拉維酸鉀耐藥率與二代頭孢和青霉素類DDDs呈中度正相關（r=0.602、0.542，P<0.05）；銅綠假單胞菌對頭孢吡肟耐藥率與三代頭孢和青霉素類DDDs呈顯著正相關（r=0.958、0.979，P<0.05）。結(jié)論 G-桿菌耐藥性變遷與抗菌藥物DDDs之間存在一定相關性。
　　[關鍵詞] 革蘭陰性桿菌；耐藥性；抗菌藥物；使用頻度；相關性
　　[中圖分類號] R446.5 [文獻標識碼] B [文章編號] 1673-9701（2018）08-0125-05
　　Correlation analysis of drug resistance changes of common Gram - negative bacilli in a hospital and frequency of using antibiotics
　　YANG Xudong1 LIANG Raan2 CHEN Ran2 DANG Heqin2 AN Rufeng2
　　1.Department of Pharmaceutics， Third People"s Hospital of Xintai City in Shandong Province， Xintai 271212， China；
　　2.Department of Pharmaceutics， Affiliated Hospital of Taishan Medical College， Tai"an 271000， China
　　[Abstract] Objective To analyze the relationship between the change of antibiotic resistance of G-bacilli and the frequency of use of antibacterials and to provide the basis for rational use of antibacterials. Methods The changes drug resistance changes of four G-bacilli were analyzed retrospectively from 2013 to 2016. The frequency of antibacterials use（DDDs） was calculated. Pearson correlation analysis was used to examine the correlation between them. Results The top four detection rates of G-bacillus were Escherichia coli， Klebsiella pneumoniae， the DDDs of Pseudomonas aeruginosa and Acinetobacter baumannii. The second and third generation of cephalosporins， diazepam and quinolones ranked the top. The drug resistance rate of Escherichia coli to levofloxacin was positively correlated with DDDs of quinolones and third generation cephalosporins（r=0.956，0.959， P<0.05）. The drug resistance rate of Klebsiella pneumoniae to piperacillin/tazobactam was moderately positively correlated with DDDs of the second generation cephalosporins（r=0.617， P<0.05）， the drug resistance rate of Klebsiella pneumoniae to Amoxicillin / Potassium claviformate was moderately positively correlated with DDDs of Penicillin and the second generation cephalosporins（r=0.602， 0.542， P<0.05）. There was a significant positive correlation between the rate of resistance to cefepime in Pseudomonas aeruginosa and DDDs of the third generation cephalosporins and penicillins（r=0.958， 0.979， P<0.05）. Conclusion There is a certain correlation between the changes of drug resistance of G-bacilli and DDDs of antibacterial drugs.

相關熱詞搜索：耐藥性 頻度 陰性 桿菌 相關性