【摘要】 目的：探究慢性蕁麻疹患者接受非索非那定與皮敏消聯(lián)合治療的價(jià)值。方法：選取2014年1月-2017年10月本院收治的慢性蕁麻疹患者280例。根據(jù)患者治療方式不同將其分為對(duì)照組（鹽酸非索非那定片）和試驗(yàn)組（鹽酸非索非那定片+皮敏消膠囊），各140例。比較兩組療效、不良反應(yīng)、治療后的生活質(zhì)量及治療前后的免疫功能指標(biāo)和炎癥因子水平。結(jié)果：試驗(yàn)組治療總有效率為97.14%，明顯高于對(duì)照組的87.86%（ 字2=8.700，P=0.003）；兩組不良反應(yīng)發(fā)生率比較，差異無統(tǒng)計(jì)學(xué)意義（P>0.05）；治療后，兩組IgA、IgG、IgM均較治療前改善，且試驗(yàn)組IgA、IgG的改善程度均優(yōu)于對(duì)照組，比較差異均有統(tǒng)計(jì)學(xué)意義（P<0.05）；治療后，兩組PCT、CRP水平均低于治療前，且試驗(yàn)組均低于對(duì)照組，比較差異均有統(tǒng)計(jì)學(xué)意義（P<0.05）；治療后，試驗(yàn)組運(yùn)動(dòng)、睡眠質(zhì)量合格率為86.43%、84.29%均高于對(duì)照組的67.86%、65.71%，比較差異均有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論：非索非那定聯(lián)合皮敏消治療慢性蕁麻疹，可促進(jìn)患者免疫功能的提高，對(duì)其炎癥因子的分泌進(jìn)行控制，更好緩解患者的蕁麻疹癥狀，改善其生活質(zhì)量，且用藥安全性較高，意義重大。
　　【關(guān)鍵詞】 非索非那定； 皮敏消； 慢性蕁麻疹
　　Efficacy of Fexofenadine Combined with Piminxiao in Treatment of Chronic Urticaria/FENG Jiaona，WEI Fangquan，HE Cuiying.//Medical Innovation of China，2018，15（07）：095-099
　　【Abstract】 Objective：To explore the value of Fexofenadine combined with Piminxiao in treatment of chronic urticaria.Method：A total of 280 patients with chronic urticaria treated in our hospital from January 2014 to October 2017 were selected.According to the different treatment methods，they were divided into control group（Fexofenadine Hydrochloride Tablets） and experimental group（Fexofenadine Hydrochloride Tablets+Piminxiao Capsule），140 cases in each group.The effects，adverse reactions，quality of life after treatment，the levels of immune function and inflammatory factors before and after treatment between two groups were compared.Result：The total effective rate of treatment group was 97.14%，which was significantly higher than 87.86% of control group（ 字2=8.700，P=0.003）.The incidence of adverse reactions in two groups was compared，the difference was not statistically significant（P>0.05）.After treatment，the IgA，IgG and IgM in two groups were all improved compared with those of before treatment，and the improvement degree of IgA and IgG in experimental group were better than those of control group，the differences were statistically significant（P<0.05）.After treatment，the levels of PCT and CRP in two groups were lower than those of before treatment，and all of experimental groups were lower than those of control group，the differences were statistically significant（P<0.05）.After treatment，the qualified rate of exercise and sleep quality in experimental group was 86.43% and 84.29%，which were higher than 67.86% and 65.71% in control group，the differences were statistically significant（P<0.05）.Conclusion：Fexofenadine combined with Piminxiao in treatment of chronic urticaria can promote the improvement of immune function，control the secretion of inflammatory cytokines，relieve urticaria symptoms and improve their quality of life，and the medication safety is higher，has a great significance.

相關(guān)熱詞搜索：蕁麻疹 療效 觀察 治療慢性 聯(lián)合