非急性腦卒中患者腦白質(zhì)疏松程度與血尿酸水平的相關性研究
發(fā)布時間:2018-06-23 來源: 歷史回眸 點擊:
摘 要:目的 探討非急性腦卒中患者的血尿酸水平與腦白質(zhì)疏松程度之間的相關性。方法 選擇2016年4月~2017年3月在承德醫(yī)學院附屬醫(yī)院神經(jīng)內(nèi)科住院的存在腦白質(zhì)疏松的患者123例,上述患者均為非急性腦卒中患者,收集所有患者臨床資料,包括:Aharon-peretz量表評分、尿酸及其它實驗室化驗指標,并進行統(tǒng)計學分析。結(jié)果 無-輕度腦白質(zhì)疏松組與中-重度腦白質(zhì)疏松組患者的尿酸水平存在顯著差異(P<0.05)。經(jīng)多因素Logistic回歸分析,尿酸是腦白質(zhì)疏松的獨立危險因素[OR值1.007,95%可信區(qū)間1.002-1.012,P=0.004]。結(jié)論 在非急性腦卒中患者中,腦白質(zhì)疏松程度越高,其體內(nèi)尿酸水平也越高。
關鍵詞:尿酸;腦白質(zhì)疏松;腦血管病
中圖分類號:R743 文獻標識碼:A DOI:10.3969/j.issn.1006-1959.2018.05.033
文章編號:1006-1959(2018)05-0101-03
Study on the Correlation between the Degree of Leukoaraiosis and the Level of Blood Uric Acid in Patients with non Acute Stroke
ZU Sai1,DOU Zhi-jie2,LU Dan-dan3,SONG Bing-bing1,WANG Pei3
。1.Chengde Medical College,Chengde 067000,Hebei,China;
2.Department of Neurology,Affiliated Hospital of Chengde Medical College,Chengde 067000,Hebei,China;
3.Baoding First Central Hospital,Baoding 071000,Hebei,China)
Abstract:Objective To investigate the correlation between serum uric acid level and the degree of leukoaraiosis in non-acute stroke patients.Methods 123 patients with leukoaraiosis were selected from April 2016 to March 2017 in Department of Neurology, Chengde medical college affiliated hospital.All of the above patients were non-acute stroke patients.All the clinical data were collected,including the score of the:Aharon-peretz scale,uric acid and other laboratory indexes and the statistical analysis was carried out.Results There was significant difference in uric acid level between non-mild leukoaraiosis group and moderate to severe leukoaraiosis group(P<0.05).By multivariate Logistic regression analysis,uric acid was an independent risk factor for leukoaraiosis[OR value 1.007,95% confidence interval 1.002-1.012,P=0.004].Conclusion n patients with non-acute stroke,the higher the degree of white matter degeneration,the higher the uric acid level in the body.
Key words:Uric acid;Leukoaraiosis;Cerebrovascular disease
腦白質(zhì)疏松癥(leukoaraiosis,LA)是圍繞腦室的白質(zhì)或者皮質(zhì)下區(qū),即半卵圓中心,在CT圖像中表現(xiàn)為較低的密度或者在MRI的T2圖像中顯示為斑片狀的邊界較為模糊的長T2信號[1]。近年普遍認為腦白質(zhì)疏松是腦小血管病的一種[2]。尿酸具有氧化性和抗氧化性雙重作用,臨床檢測較為便捷,其與腦白質(zhì)疏松的關系近年來開始引起人們的關注。本文對血尿酸水平與腦白質(zhì)疏松的相關性進行了分析。
1 資料與方法
1.1一般資料 選取2016年4月~2017年3月在承德醫(yī)學院附屬醫(yī)院住院的患者123例,且均經(jīng)頭顱磁共振檢查,確診為LA。本實驗通過醫(yī)院醫(yī)學倫理委員會審定。納入標準:①無任何精神類疾病;②無其他系統(tǒng)嚴重疾病;③患者及家屬對本研究知情同意同意。排除標準:①排除急性期腦卒中患者;②排除退行性認知功能障礙患者;③排除嚴重失語、聽力減退或昏迷等不能正常交流的患者;④排除由慢性酒精中毒、中樞神經(jīng)系統(tǒng)感染以及頭部外傷而出現(xiàn)繼發(fā)性認知功能障礙患者;⑤排除既往痛風病史及服用相關藥物的患者。
熱點文章閱讀