大全寶光散熏蒸治療肝胃郁熱夾瘀型糖尿病干眼癥的臨床研究
發(fā)布時間:2018-06-24 來源: 美文摘抄 點擊:
摘要:目的 觀察比較不同治療措施對肝胃郁熱夾瘀型糖尿病干眼癥的臨床療效。方法 將65例肝胃郁熱夾瘀型糖尿病干眼癥患者隨機分為熏蒸組與針刺組各33例。觀察2組患者治療前后眼部癥狀積分、SIT、BUT、FL、角膜知覺的影響的變化。結(jié)果 經(jīng)過2個療程治療后,2組患者各指標較治療前有顯著改善(P<0.05)。熏蒸組總有效率較針刺組無明顯差異(P>0.05),2組治療后在眼部癥狀積分、SIT、BUT、FL、角膜知覺方面無明顯差異(P>0.05)。結(jié)論 大全寶光散熏蒸療效與普通針刺相同,在改善眼部癥狀積分和淚液分泌試驗、淚膜破裂時間及角膜熒光染色、角膜知覺方面2者無明顯差異,具有無創(chuàng)、便捷的優(yōu)點。
關鍵詞:糖尿病干眼癥;大全寶光散;熏蒸;針刺
中圖分類號:R255.4 文獻標志碼:B 文章編號:1007-2349(2018)02-0059-04
Clinical Study on Treatment of Diabetes Xerophthalmia Patients with Liver-stomach Hot and
Suffocating Stasis by Daquan Baoguang Powder Fumigation
DONG Hui-jie1, YAN Qing1, TIAN Qiang1, SONG Li1, ZHANG Yuan-chen1, DANG Yu-qi2
。1. Ningxia Medical University, Yinchuan 750001, China;
2. Traditional Chinese Medicine Hospital of Yinchuan City, Yinchuan 750001, China)
【Abstract】Objective: To observe and compare the clinical curative effect of different measures on treatment of diabetes xerophthalmia patients with liver-stomach hot and suffocating stasis by Daquanguangbao Powder fumigation. Methods: 65 patients were randomly divided into a fumigation group (33 cases) and an acupuncture group (32 cases). The changes of ocular symptom scores, SIT, BUT, FL and corneal sensation of the two groups before and after treatment were observed. Results: After two courses of treatment, the indexes in the two groups improved significantly (P<0.05). The total effective rate of the fumigation group was not significantly different from that of the acupuncture group (P>0.05). There was no significant difference in the eye symptom score, SIT, BUT, FL and corneal perception between the two groups after the treatment (P>0.05). Conclusion: The effect of Daquan Baoguang Powder fumigation is the same as that of ordinary acupuncture. There is no significant difference between the two groups in the improvement of eye symptom scores and tear secretion test, tear film rupture time as well as corneal fluorescence staining and corneal sensation, but it has the advantages of non-invasiveness and conveniency.
【Key words】diabetes xerophthalmia, Daquan Baoguang Powder, fumigation, acupuncture
糖尿病干眼癥是糖尿病眼疾常見并發(fā)癥之一,有研究表明,糖尿病高糖狀態(tài)可引起瞬目減少、淚膜穩(wěn)定性下降,另外糖尿病周圍神經(jīng)病變使角膜知覺減退,可引起淚腺分泌減低,進一步加劇了糖尿病干眼癥的發(fā)生[1]。據(jù)不完全統(tǒng)計,我國2型糖尿病合并干眼癥的患病率在50 %以上[2]。其主要癥狀有眼部的干澀感、燒灼感、癢感、異物感、眼紅、畏光、視力波動、視物不清等,輕者影響工作和生活,嚴重者可致眼表尤其是角膜組織干燥和穿孔而影響視力。
本課題采用隨機對照臨床試驗研究,通過觀察大全寶光散熏蒸與針刺治療后患者眼部癥狀積分、淚液分泌實驗、淚膜破裂時間、角膜熒光素染色及角膜知覺的變化,觀察不同治療方法對糖尿病干眼癥臨床效果的影響。
1 臨床資料
1.1 一般資料 65例患者來源于2016年9月—2017年9月在寧夏醫(yī)科大學附屬銀川市中醫(yī)醫(yī)院糖尿病科住院部或門診就診的肝胃郁熱夾瘀型糖尿病干眼癥患者,均符合本研究的納入標準及排除標準。采用隨機數(shù)字表法從《醫(yī)學統(tǒng)計學》(人民衛(wèi)生出版社出版 孫振球 徐勇勇主編 第四版)附錄二隨機數(shù)字表隨機行列開始,選取70個小于70的隨機數(shù)字,從小到大排序,以前35個較小數(shù)為A組,后35個較大數(shù)為B組,規(guī)定A組為熏蒸組,B組為針刺組。將70個隨機數(shù)字放入信封,根據(jù)患者就診順序打開信封,按獲得數(shù)字隨機將患者分為2組。剔除5例后,熏蒸組33例66只眼,針刺組32例64只眼,2組患者性別、年齡、病程、眼部癥狀積分、淚液分泌實驗、淚膜破裂時間、角膜熒光素染色、角膜知覺部分比較差異無統(tǒng)計學意義(P>0.05),具有可比性。見表1。
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