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        阿司匹林抵抗與冠心病合并2型糖尿病患者M(jìn)ACE的臨床關(guān)系

        發(fā)布時間:2018-06-23 來源: 人生感悟 點(diǎn)擊:

        http://img1.qikan.com.cn/qkimages/zsyx/zsyx201812/zsyx20181202-1-l.jpg
          【摘要】 目的 探討阿司匹林抵抗(AR)與冠心病合并2型糖尿病患者不良心血管事件(MACE)發(fā)生的關(guān)系。方法 120例冠心病合并2型糖尿病患者, 根據(jù)是否發(fā)生AR分為AR組與非AR組, 比較兩組的MACE發(fā)生情況, 并根據(jù)患者是否發(fā)生MACE分為發(fā)生組與未發(fā)生組, 比較患者的一般資料, 進(jìn)而分析AR等與冠心病合并2型糖尿病患者發(fā)生MACE的關(guān)系。結(jié)果 AR組MACE發(fā)生率51.43%明顯高于非AR組的23.53%, 差異具有統(tǒng)計學(xué)意義(P<0.05)。發(fā)生組性別、收縮壓、舒張壓、總膽固醇(TC)、高密度脂蛋白膽固醇(HDL-C)、空腹血糖(FBG)水平與未發(fā)生組比較差異無統(tǒng)計學(xué)意義(P>0.05);發(fā)生組年齡、體質(zhì)量指數(shù)(BMI)、三酰甘油(TG)、低密度脂蛋白膽固醇(LDL-C)、糖化血紅蛋白(HbA1c)、AR發(fā)生情況與未發(fā)生組比較差異具有統(tǒng)計學(xué)意義(P<0.05)。經(jīng)Logistic分析分析, 年齡、LDL-C、HbA1c、AR是影響MACE發(fā)生的因素(P<0.05)。結(jié)論 存在AR的冠心病合并糖尿病患者發(fā)生MACE的風(fēng)險更高, 年齡、LDL-C、HbA1c、AR均是導(dǎo)致MACE發(fā)生的危險因素。
          【關(guān)鍵詞】 阿司匹林抵抗;2型糖尿病;不良心血管事件;冠心病
          DOI:10.14163/j.cnki.11-5547/r.2018.12.002
          【Abstract】 Objective To investigate the relationship between aspirin resistance (AR) and main adverse cardiovascular events (MACE) in patients with type 2 diabetes mellitus complicated with coronary heart disease. Methods A total of 120 patients with type 2 diabetes mellitus complicated with coronary heart disease were divided by occurrence of AR into AR group and non-AR group. The occurrence of MACE in the two groups was compared, and the patients were divided by occurrence of MACE into the occurrence group and non-occurrence group. The general data of patients was compared, and then the relationship between AR and MACE in patients with coronary heart disease and type 2 diabetes mellitus was analyzed. Results AR group had obviously higher incidence of MACE as 51.43% than 23.53% in non-AR group, and the difference was statistically significant (P<0.05). The occurrence group had no statistically significant difference in gender, systolic blood pressure, diastolic blood pressure, total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), and fasting blood glucose (FBG) level, comparing with non-occurrence group (P>0.05). The occurrence group had statistically significant difference in age, body mass index (BMI), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), glycosylated hemoglobin (HbA1c) and AR occurrence, comparing with non-occurrence group (P<0.05). According to Logistic analysis, age, LDL-C, HbA1c and AR were factors affecting the occurrence of MACE (P<0.05). Conclusion There is a higher risk of MACE in patients with coronary heart disease and diabetes mellitus who have AR. Age, LDL-C, HbA1c and AR are all risk factors for the occurrence of MACE.
          【Key words】 Aspirin resistance; Type 2 diabetes mellitus; Main adverse cardiovascular events; Coronary heart disease
          多數(shù)冠心病患者合并有2型糖尿病, 二者;橐蚬, 加重患者的病情, 增加MACE的發(fā)生風(fēng)險[1, 2]?寡“逯委熓穷A(yù)防心血管疾病和血栓事件發(fā)生的重要手段, 受到個體差異影響, 不同個體對抗血小板藥物治療的反應(yīng)存在差異, 在接受抗血小板藥物治療仍會發(fā)生血栓事件, 即“血小板抵

        相關(guān)熱詞搜索:阿司匹林 冠心病 糖尿病患者 抵抗 合并

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