[摘要]目的 探討藥物干預(yù)對(duì)晚期腫瘤合并抑郁狀態(tài)患者生活質(zhì)量的影響。方法 選擇2012年4月～2016年4月在我院診斷治療的晚期腫瘤合并標(biāo)準(zhǔn)抑郁狀態(tài)的患者214例，采用隨機(jī)數(shù)字表法將其分為實(shí)驗(yàn)組112例，對(duì)照組102例，對(duì)照組患者進(jìn)行常規(guī)的抗腫瘤治療，實(shí)驗(yàn)組在對(duì)照組治療基礎(chǔ)上，每日早、午飯后各予1片氟哌噻噸美利曲辛片治療，>60歲的患者每日早飯后服用1片氟哌噻噸美利曲辛片。1、2、3、4周后再次用QOL量表進(jìn)行評(píng)分。結(jié)果 實(shí)驗(yàn)組患者第4周后數(shù)值高于第0組，差異有統(tǒng)計(jì)學(xué)意義（P<0.05），實(shí)驗(yàn)組患者治療后QOL評(píng)分高于對(duì)照組，差異均有統(tǒng)計(jì)學(xué)意義（P<0.05），實(shí)驗(yàn)組的副作用高于對(duì)照組（P<0.05）。結(jié)論 晚期腫瘤合并抑郁狀態(tài)聯(lián)合應(yīng)用氟哌噻噸美利曲辛藥物干預(yù)，可提高晚期腫瘤合并抑郁狀態(tài)患者的生活質(zhì)量，無明顯不良反應(yīng)，值得臨床應(yīng)用。
　　[關(guān)鍵詞]晚期腫瘤；抑郁狀態(tài)；氟哌噻噸美利曲辛片
　　[中圖分類號(hào)] R732 [文獻(xiàn)標(biāo)識(shí)碼] A [文章編號(hào)] 1674-4721（2018）2（b）-0080-03
　　Influence of drug intervention on the quality of life in patients with advanced tumor and depression
　　GAO Jin-suo WANG Jian-bing LIU Wei-wei YANG Jin-zhu
　　Department of Oncology，the Third People′s Hospital of Hefei City in Anhui Province，Hefei 230022，China
　　[Abstract]Objective To investigate the effect of drug intervention on quality of life in patients with advanced tumor and depression.Methods From April 2012 to April 2016，214 patients with advanced tumor complicated with standard depression were selected and randomly divided into experimental group（112 cases），control group（102 cases）and control group （102cases）.The patients in the experimental group were treated with conventional anti-tumor therapy.on the basis of the treatment of the control group，the patients in the experimental group were treated with one tablet of Flupentixol Melitracen every morning and one tablet of Flupentixol Melitracen every day after lunch，and the patients>60 years old were treated with 1 tablet of Flupentixol Melitracen every day after breakfast. After 1，2，3 and 4 weeks，QOL scale was used to score again.Results The QOL score of the experimental group at week 1-4 was significantly higher than that before treatment （P<0.05）.The QOL score of the experimental group was higher than that of the control group（P<0.05），and the side effect of the experimental group was higher than that of the control group （P<0.05）.Conclusion Drug intervention of Flupentixol Melitracen can improve QOL of patients with advanced tumor combined with depression，and without obvious adverse reactions，is worthy of clinical application.
　　[Key words]Advanced tumor；Depression；Flupentixol and Melitracen Tablets
　　目前的醫(yī)學(xué)模式是生物-心理-社會(huì)醫(yī)學(xué)模式 [1]。隨著醫(yī)學(xué)模式的轉(zhuǎn)變，生活質(zhì)量（quality of life，QOL） 的概念漸漸引入醫(yī)學(xué)研究中[2]。近20 年來，QOL 己被廣泛應(yīng)用于各種慢性病防治，特別是腫瘤患者治療效果的評(píng)價(jià)上，成為癌癥治療臨床試驗(yàn)的終點(diǎn)之一[3]。晚期腫瘤患者合并抑郁癥比例高，危害患者的生活質(zhì)量，嚴(yán)重的抑郁癥甚至是癌癥患者自殺傾向[4]。臨床醫(yī)師對(duì)晚期腫瘤合并抑郁癥的關(guān)注也較少。我們應(yīng)用漢密爾頓抑郁量表（HRSD）及QOL量表，對(duì)晚期患者進(jìn)行調(diào)查，對(duì)符合診斷標(biāo)準(zhǔn)的患者，選用氟哌噻噸美利曲辛片對(duì)晚期腫瘤患者合并有抑郁狀態(tài)患者進(jìn)行藥物干預(yù)，觀察晚期患者生活質(zhì)量的改變，現(xiàn)報(bào)道如下。

相關(guān)熱詞搜索：晚期 干預(yù) 生活質(zhì)量 腫瘤 合并