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        塘棲產(chǎn)枇杷葉的藥材品質(zhì)分析

        發(fā)布時間:2019-08-30 來源: 短文摘抄 點擊:


          [摘要] 目的 評估塘棲產(chǎn)不同品種枇杷葉的藥材品質(zhì)。 方法 參照2015版《中國藥典》,采用烘干法、灼燒法、熱浸法分析測定塘棲產(chǎn)不同品種枇杷葉的水分、總灰分和浸出物含量;采用Kromasil C18(250 mm×4.6 mm,5 μm)色譜柱,以乙腈-甲醇-0.5%醋酸銨(67∶12∶21,v/v/v)為流動相,柱溫25℃,流速為1.0 mL/min,檢測波長為210 nm,對齊墩果酸和熊果酸的含量進行測定。采用Kromasil C18(250 mm×4.6 mm,5 μm)色譜柱,以甲醇-0.4%磷酸水溶液(50∶50,v/v)為流動相,柱溫30℃,流速為1.0 mL/min,檢測波長為360 nm,對槲皮素和山奈酚的含量進行測定。結(jié)果 塘棲產(chǎn)各品種枇杷葉水分、總灰分、浸出物含量范圍分別為7.87%~9.45%、5.14%~6.22%、25.41%~29.68%;齊墩果酸和熊果酸的含量總和范圍為1.04%~1.25%,均符合2015版《中國藥典》的標(biāo)準(zhǔn);此外,枇杷葉中的槲皮素和山奈酚的總含量范圍為0.17%~0.29%。 結(jié)論 塘棲產(chǎn)地的不同品種枇杷葉均具有較好的品質(zhì),值得進一步開發(fā)利用。
          [關(guān)鍵詞] 枇杷葉;齊墩果酸;熊果酸;總黃酮
          [中圖分類號] R284.1 [文獻標(biāo)識碼] A [文章編號] 1673-7210(2018)10(c)-0111-04
          [Abstract] Objective To evaluate the quality of different varieties of loquat leaves from Tangxi. Methods Reference to the 2015 edition of Chinese Pharmacopoeia, the water content, total ash content and extract content of different varieties of loquat leaves were measured by oven drying method, ignition method and hot-dip method. The oleanolic acid and ursolic acid were detected useing Kromasil C18 (250 mm×4.6 mm, 5 μm) column, with mobile phase being acetonitrile-methanol-0.5% ammonium acetate (67∶12∶21, v/v/v), column temperature being at 25℃, flow velocity being 1.0 mL/min, and detection wavelength being at 210 nm. The quercetin and kaempferol were detected by Kromasil C18(250 mm×4.6 mm,5 μm)column, with mobile phase being methanol-0.4% phosphoric acid (50∶50, v/v), column temperature being at 30℃, flow velocity being 1.0 mL/min, and detection wavelength being at 360 nm. Results The range of water content, total ash content, and extract content of different varieties of loquat leaves were 7.87%-9.45%, 5.14%-6.22% and 25.41%-29.68%, respectively, the range of total content of oleanolic acid and ursolic acid was 1.04%-1.25%, all in line with the 2015 edition of Chinese Pharmacopoeia. In addition, the range of total content of quercetin and kaempferol in loquat leaves was 0.17%-0.29%. Conclusion The different varieties of loquat leaves in Tangxi all have good quality and deserve further development and utilization.
          [Key words] Loquat leaf; Oleanolic acid; Ursolic acid; Total flavonoid
          枇杷葉是一味臨床常用傳統(tǒng)中藥,來源于薔薇科植物枇杷Eriobotrya japonica(Thunb.)Lindl.的干燥葉片,收載于歷版《中國藥典》[1]中,性微寒,味苦辛,歸肺、胃經(jīng),具有清肺止咳、降逆止嘔等功效,是目前中醫(yī)常用藥,臨床使用量大,F(xiàn)代藥理研究表明,枇杷葉中的化學(xué)成分結(jié)構(gòu)多樣,主要有三萜酸類、黃酮類、倍半萜、多酚類、糖苷類以及揮發(fā)油類化合物[2-7]。近年來研究表明枇杷葉除具有較好的抗炎和止咳作用外,還具有其他廣泛的藥理作用,如降血糖、抗腫瘤、抗病毒、保肝和抗氧化等[2,8-17]。通過對枇杷葉化學(xué)成分和藥理作用的研究,可以看出枇杷葉這一傳統(tǒng)中藥具有多方面的用途,可用于多種疾病的預(yù)防和治療,并取得了良好的療效。
          我國枇杷資源豐富,主要分布于浙江、江西、廣東、福建、臺灣、四川、貴州、云南、陜西、甘肅、江蘇、安徽等地。其中杭州市余杭區(qū)塘棲鎮(zhèn)是全國著名的枇杷產(chǎn)區(qū)之一,枇杷栽種歷史悠久,有“中國枇杷之鄉(xiāng)”的美譽。檢索文獻發(fā)現(xiàn),雖然關(guān)于枇杷葉的相關(guān)研究報道很多,但目前還沒有關(guān)于塘棲枇杷葉品質(zhì)的文獻報道,對塘棲這一主要枇杷產(chǎn)地枇杷葉系統(tǒng)研究尚未進行過,這與其果實品質(zhì)不相稱。本研究對塘棲產(chǎn)不同種源枇杷葉的水分、總灰分、浸出物、齊墩果酸、熊果酸和總黃酮含量進行了分析測定,旨在為塘棲枇杷葉資源利用提供科學(xué)依據(jù),F(xiàn)報道如下:

        相關(guān)熱詞搜索:藥材 品質(zhì) 分析 枇杷葉 塘棲產(chǎn)

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