高血壓對腦卒中高危人群頸動脈粥樣硬化發(fā)生的影響及其病機探討
發(fā)布時間:2018-06-24 來源: 短文摘抄 點擊:
[摘要] 目的 分析高血壓對腦卒中高危人群頸動脈粥樣硬化發(fā)生的影響及其病機。方法 方便選擇2011年1月—2015年12月該院收治的210例腦卒中高危人群,根據(jù)有無高血壓作為分組標準分為試驗組146例和對照組64例,分析兩組一般資料、CCA-IMT情況、頸動脈斑塊檢出情況以及病程與疾病進展的關(guān)系。結(jié)果 試驗組與對照組在年齡、性別、吸煙史、體重指數(shù)方面差異無統(tǒng)計學意義(P>0.05),具有可比性。對照組和實驗組左右側(cè)CCA-IMT增厚檢出率分別為39.06%、32.81%和60.96%、46.58%,試驗組檢出率明顯高于對照組,差異有統(tǒng)計學意義(P<0.05)。高血壓病程與CCA-IMT增厚存在相關(guān)性,病程增加,內(nèi)膜增厚比例增加(χ2=9.304,P<0.05)。高血壓病程與頸動脈斑塊檢出存在一定關(guān)系,隨著高血壓病程增加,頸動脈斑塊檢出率增加(χ2=10.344,P<0.05)。結(jié)論 臨床需加強腦卒中的篩查防治工作,特別是針對伴有高血壓的腦卒中高危人群,積極采取有效的預防與治療措施,將降低腦卒中的發(fā)生。
[關(guān)鍵詞] 高血壓;頸動脈粥樣硬化;影響與病機
[中圖分類號] R4 [文獻標識碼] A [文章編號] 1674-0742(2018)01(c)-0068-03
[Abstract] Objective This paper tries to analyze the effect of hypertension on carotid atherosclerosis and its pathogenesis. Methods 210 cases of high-risk of stroke in this deparment from January 2011 to December 2015 were selected, and divided into two groups by having hypertension or not, 146 cases in the trial group, and 64 cases in the control group. The relationship between the disease progression with the general information, CCA-IMT and the carotid plaques was analyzed. Results The difference in age, gender, smoking history and body mass index of the two groups were not significant. There was no statistical significance, and they were comparable(P>0.05). The detection rates of CCA-IMT thickening in the left and right sides of control group and trial group were 39.06%, 32.81% and 60.96%, 46.58%, respectively. The detection rate of trial group was higher than that of the control group, the difference was statistically significant(P<0.05). Hypertension was associated with CCA-IMT, with the longer hypertension duration, the rate of the CCA-IMT increased(χ2=9.304,P<0.05). Hypertension was associated with the carotid plaques, with the longer hypertension duration, the detection rate of the carotid plaques increased(χ2=10.344,P<0.05). Conclusion Clinical need to strengthen screening and prevention and treatment of stroke, especially for high-risk stroke associated with hypertension crowd, and actively take effective preventive and therapeutic measures will reduce the incidence of stroke.
[Key words] Hypertension; Carotid atherosclerosis; Influence and pathogenesis
腦卒中作為一種急性腦血管疾病,包括缺血性腦卒中和出血性腦卒中。其中前者的發(fā)病率要明顯高于后者。頸內(nèi)動脈、椎動脈閉塞和狹窄會引發(fā)缺血性腦卒中,主要發(fā)生在40多歲以上的男性患者。相關(guān)研究發(fā)現(xiàn),清晨高血壓是卒中事件最強的獨立預測因素,缺血性卒中在清晨時段發(fā)生的風險是其他時段的4倍[1],清晨血壓每升高10 mmHg,卒中風險增加44%[2]。而頸內(nèi)動脈或椎動脈狹窄和閉塞的主要原因就是動脈粥樣硬化。越來越多研究證實,高血壓是中國人群卒中發(fā)病的最重要危險因素[3]。介于此,該文對2011年1月—2015年12月該院收治的210例腦卒中高危人群進行頸動脈粥樣硬化的相關(guān)變化進行研究,現(xiàn)具體報道如下。
1 資料與方法
1.1 一般資料
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